Abstract # 4415 Poster # 94:

Scheduled for Thursday, June 20, 2013 07:00 PM-09:00 PM: Session 9 (SG Foyer ABC) Poster Presentation


CHRONIC SEROTONIN 1A AGONISM INCREASES PLASMA OXYTOCIN BUT SELECTIVELY DECREASES AFFILIATION IN THE TITI MONKEY (CALLICEBUS CUPREUS)

R. H. Larke1,2, N. Maninger2, S. P. Mendoza2 and K. L. Bales1,2
1University of California, Davis, Psychology Department, Davis, California, USA, 2California National Primate Research Center, University of California, Davis, Davis, California, USA
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     Titi monkeys (Callicebus cupreus) are a monogamous primate that form lasting pair-bonds characterized by selective preference for the pair-mate, social buffering, and a physiological and behavioral response to separation. In this study we examined how pharmacological activation of the serotonin 1A receptor affects social behavior, and peripheral hormones in the adult male titi monkey in an established pair bond. Eight male subjects were administered 0.1mg/kg 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT, a selective serotonin 1A receptor agonist) or saline vehicle daily for 15 consecutive days. Blood samples were taken 15 and 45 minutes post injection on days 1, 3, 8, 10 and 15. Behavior was recorded daily for 30 minutes with the pair-mate and coded for locomotor, sexual, arousal and aggressive behavior. Blood plasma was assayed for oxytocin, vasopressin and cortisol. Results indicate that 8-OH-DPAT increases plasma oxytocin (F=11.3, p=.001) but not arginine vasopressin (F=3.56, p>.05). Behaviorally, there appeared to be two sub-populations with regard to sensitivity to 8-OH-DPAT, which predicted affiliative behavior post-injection. In addition, male initiation of physical contact was not affected by 8-OH-DPAT on day 1, but was significantly reduced after chronic treatment (F=2.65, p<.05). Funding: Autism Science Foundation Pre-doctoral fellowship, NIH HD053555, Office of Research Infrastructure Programs, grant P51OD011107, and the Good Nature Institute.