Abstract # 4419 Event # 26:

Scheduled for Thursday, June 20, 2013 12:00 PM-12:15 PM: Session 2 (San Geronimo Ballroom B) Symposium


LONG-TERM EFFECTS OF CASTRATION ON THE SKELETON OF MALE RHESUS MONKEYS (MACACA MULATTA)

M. J. Kessler1, A. M. Cerroni2, M. D. Grynpas2, K. Pritzker2, R. G. Rawlins1, T. B. Kensler1, O. D. Gonzalez1 and J. Gonzalez-Martinez1
1Caribbean Primate Research Center, University of Puerto Rico Medical Sciences Campus (UPR), Sabana Seca, PR 00952-1053, USA, 2University of Toronto
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     Osteoporosis (OPO) has been studied in various species of aging nonhuman primates (NHPs) and extensively in ovariectomized rhesus and cynomolgus macaques, but there is virtually no information on the effects of castration on the skeleton of male NHPs. Only one report was found: a short-term study on common marmosets (Callithrix jacchus). Rhesus skeletons from the Caribbean Primate Research Center's Cayo Santiago skeletal collection were used to compare the bone density of castrated and intact males. Femurs, vertebrae and the crania were evaluated using digital radiography and dual-energy X-ray absorptiometry (DXA). Results showed that rhesus males castrated as yearlings or young adults develop osteopenia (OPE) or OPO over time. These changes are similar to those found in eunuchs: thinning of the skull, thinning and increased porosity of the femur including loss of trabecular bone in the neck and cortical bone in the shaft, increased porosity of the vertebrae with fragile fractures eventually causing severe osteoarthritis and kyphosis, and failure of closure and avulsion of the epiphyses in monkeys castrated as yearlings. The castrated male rhesus macaque should be an excellent model for studying the long-term effects of castration on bone and other tissues/organs, and should be useful to test hormone replacement therapies for men orchiectomized for prostate or testicular cancer. This study was supported by NIH grant 8-P40-OD012217-25, UPR and the University of Toronto.