Abstract # 87:

Scheduled for Thursday, June 20, 2013 07:00 PM-09:00 PM: Session 9 (SG Foyer ABC) Poster Presentation


THE ROLE OF DOPAMINE D-1 RECEPTORS IN PAIR-BOND MAINTENANCE IN MONOGAMOUS TITI MONKEYS (CALLICEBUS CUPREUS).

E. S. Rothwell1,2,4, S. P. Mendoza1,2,3, W. A. Mason1,2,3, B. J. Ragen1,2,3 and K. L. Bales1,2,3,4
1University of California- Davis, One Shields Ave, Davis, CA 95616, USA, 2California National Primate Research Center, 3Psychology Department, 4Animal Behavior Graduate Group
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     Dopamine, involved in motivation and reward, is also involved in monogamous pair-bonding. In monogamous rodents dopamine D1 receptor activity regulates pair-bond maintenance by facilitating territorial aggression. We investigated the role of D1 receptors in pair-bond maintenance for a monogamous primate. Titi monkeys form strong and selective pair-bonds characterized by mate guarding. We administered a low or high dose (0.01, 0.1 mg/kg) of SCH23390 (D1 antagonist) or saline vehicle intramuscularly to eight adult pair-bonded males. Following drug uptake we presented a mirror to the male and his mate to simulate an intruder and elicit arousal and mate guarding responses. The non-reflective back of the mirror served as a control. Behavior was video-recorded for subsequent analysis. Blood samples were collected thirty minutes following mirror exposure for assay of plasma cortisol concentrations. We hypothesized that SCH23390 would diminish arousal and mate guarding responses to the mirror. Preliminary analyses suggest the mirror was an effective stimulus in eliciting behavioral arousal. As found previously, physiological arousal did not accompany the increased behavioral arousal to the mirror. Mixed models analysis revealed that the high dose of SCH23390 lead to significantly higher cortisol levels during testing compared to the low dose [p < 0.01] and saline [p < 0.01]. This suggests that D1 receptors did not mediate mirror-specific arousal responses via the HPA axis and that another mechanism may be at work.