Abstract # 4558 Poster # 179:

Scheduled for Friday, June 21, 2013 07:00 PM-09:00 PM: Session 21 (SG Foyer ABC) Poster Presentation


EFFECT OF ESTRADIOL REPLACEMENT ON BEHAVIOR, COGNITION AND BRAIN ACTIVITY IN MIDDLE-AGED FEMALE MARMOSETS (CALLITHRIX JACCHUS)

M. G. LaClair1, J. Chang1, C. M. Metevier1, J. S. Meyer1, C. M. Ferris2 and A. Lacreuse1
1University of Massachusetts, Amherst , MA 01003, USA, 2Northeastern University, Boston MA 02115
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The common marmoset has been identified as a useful nonhuman primate model for aging studies. We examined whether behavior, cognition and brain activity, as assessed by functional magnetic resonance imaging, were sensitive to estrogen manipulations in middle-aged female marmosets. Twelve ovariectomized females (3-5 years old) were implanted with 17-β estradiol Silastic capsules (E2, n=6) or empty capsules (controls, n=5). E2 plasma levels were higher in the E2 than in the control group (t(9) = 6.60, p <.001). Modified frequency scoring was used to record the occurrence of 25 behaviors in 15s intervals for 5 min. Cognition was assessed with the Object Reversals, Delayed Response (DR), Detour Reaching and acquisition of a Delayed Matching-to-Position (DMP).  Behavior did not differ significantly between the two groups. However, E2-treated monkeys tended to make more errors than the controls in the DR (F(1, 9) = 3.90, p = 0.08, effect size ES = 0.66) and to outperform the controls in DMP learning (trials t(9) = 1.38, p = .10, ES = 0.83; errors t(9) = 1.38, p = .09, ES = 0.86, one-tailed). Preliminary imaging results (n = 8) indicated that E2-treated monkeys had greater activation than controls in multiple brain regions when shown novel vs. habituated marmoset faces. The results suggest that female marmosets are useful to study the effects of estrogens on neurocognitive function. Supported by MH091492.