Abstract # 159:

Scheduled for Friday, June 21, 2013 07:00 PM-09:00 PM: Session 21 (SG Foyer ABC) Poster Presentation


A BARRIER COLONY OF SPF COMMON MARMOSETS

C. N. Ross, S. D. Tardif and S. Austad
Barshop Institute for Longevity & Aging Studies, University of Texas Health Science Center San Antonio, San Antonio, TX 78245-3207, USA
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     As small, short-lived, and fast producing primates marmosets (Callithrix jacchus) are a potentially unique model for aging, and healthspan research. A barrier maintained SPF colony of marmosets was established in 2007 at the Barshop Institute for Longevity and Aging Studies in order to provide a healthy source of marmosets for biomedical research. Founding marmosets were screened for Giardia, Cryptosporidium, Clostridium, Campylobacter, GBV Virus A, and Callitrichine herpes virus. Colony size has increased from the founding 11 animals to 65 animals. Female reproduction has remained at an outstanding level of 3.4 viable offspring per female per year which contrasts with 1.6-1.8 viable offspring per year in our conventional colony. Blood samples collected during 2012 from all individuals over 6 months of age at our barrier as well as age- and gender-matched individuals at the conventional colony were evaluated for clinical blood chemistry parameters as well as complete blood counts. Marmosets in the barrier had significantly fewer neutrophils in a CBC count (F(1,106) = 4.532, p = 0.036), and the blood chemistry revealed significantly higher BUN (F(1,68) = 18.165, p= 0.0001), and lower CRE (F(1,68) = 5.02, p=0.028). All of these values are within the normal reported range for marmosets and these differences may reflect differences in the diet, rather than health differences. Overall the colony has had few adult deaths, and no signs of infectious disease.