Abstract # 24:

Scheduled for Thursday, June 20, 2013 11:30 AM-11:45 AM: Session 2 (San Geronimo Ballroom B) Symposium


FAMILIAL CIRCADIAN RHYTHM DISORDER IN THE DIURNAL PRIMATE, MACACA MULATTA

I. Zhdanova1,2
1Boston University, 72 E.Concord Av.R-913, Boston, MA 02118, USA, 2Caribbean Primate Research Center
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     Alterations in the circadian clock can lead to internal desynchrony between individual body rhythms or their misalignment with periodically changing environment, increasing a risk for multiple human disorders. The inverse temporal relationship of central clock activity to physiological or behavioral outputs in diurnal and nocturnal species, makes diurnal primates helpful in understanding the mechanisms and physiological consequences of circadian disorders in humans. Following a discovery of the first known intrinsic circadian disorder in three closely related non-human primates (NHP) (Zhdanova et al, 2012), we have monitored entrained and intrinsic circadian rhythms of activity, food intake and cognitive performance in their 25 relatives (age 5.5-27, both genders). Studies were conducted over 9 consecutive months, in light-dark cycle and under constant dim light, revealing that the majority of animals studied have intrinsic misalignment of the circadian rhythms of activity and food intake, a delay in their entrainment to the light-dark cycle or, in the extreme cases, a complete loss of circadian rhythmicity. These data, suggesting an autosomal with high penetrance circadian disorder, provides new opportunities for studying intrinsic circadian abnormalities consistent with two human conditions, the delayed sleep phase disorder (DSPD) and night eating syndrome (NES). This model should help understanding the molecular mechanisms and developing effective therapeutic strategies for these human disorders. Supported by NIH/NIA and Chaikin-Wile Foundation.