Abstract # 209:

Scheduled for Saturday, June 22, 2013 11:00 AM-11:30 AM: Session 25 (San Geronimo Ballroom C) Oral Presentation


CSF A BETA LEVELS, COGNITION, AND CIRCADIAN SLEEP-WAKE MEASURES IN AGED NONHUMAN PRIMATES.

J. Raber
Dept Behav Neurosci and Neurol, Div Neurosci, ONPRC, OHSU, OHSU, L470, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
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Introduction: Cognition is negatively impacted by disruptions in circadian activity, especially in the elderly. M1 muscarinic receptor function and immune measures also affect cognition. We tested the hypothesis that performance in a spatial food port task is associated with circadian activity, M1 receptor binding, and immune measures.

Methods: Data were collected of 16 female rhesus monkeys (Macaca mulatta, 19–25 years).

Results: Spatial cognition correlates with circadian sleep-wake measures and hippocampal muscarinic type 1 (M1) receptor binding. When the cognitively characterized animals are classified as good spatial performers (GSP) or poor spatial performers (PSP), the GSP group has a higher frequency of CD8, but not CD4, interferon-g (IFN-g) producing cells following vaccination compared to the PSP group. The number of CD-8 IFN-g positive cells correlates with measures of sleep quality.

Conclusion: Spatial cognition in aged female macaques is associated with circadian activity, M1 receptor binding, and immune measures following vaccination. Amyloid-beta (Ab) accumulation in the brain extracellular space is a hallmark of Alzheimer's disease (AD). As very mild and mild AD patients have reduced A? levels in the CSF and the amount of Ab in the interstitial fluid correlates with wakefulness and is increased during acute sleep deprivation, we started to assess CSF Ab levels in these aged animals to determine whether they are correlated with cognition and measures of sleep quality.