Abstract # 4648 Poster # 166:

Scheduled for Friday, June 21, 2013 07:00 PM-09:00 PM: Session 21 (SG Foyer ABC) Poster Presentation


THE USE OF MEDICATED FEED TO TREAT A SHIGELLOSIS EPIZOOTIC IN A FREE-RANGING COLONY OF RHESUS MACAQUE (MACACA MULATTA).

A. G. Burgos1, A. Ruiz1 and A. Mejia2
1Caribbean Primate Research Center, 00959. , Sabana Seca, Puerto Rico 00959, USA, 2Wisconsin National Primate Research Center
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     Shigellosis is among the most common enteric pathogen in nonhuman primates. Treatment for Shigellosis combines the use of fluid therapy and antimicrobials. In the following report we were able to theorize the use of medicated feed as a safe and effective modality to treat a free-ranging rhesus macaque colony against a Shigella epizootic. Sixty animals were divided into 2 groups of thirty in which one group received only medicated feed and another group received oral trimethoprim-sulfamethoxazole via orogastric tube. Fecal samples were collected for cultures prior and post treatment. Bloodwork was performed before, during and after treatment. Fecal culture prior to feed trial revealed positive results on both groups for Shigella flexneri. On day 14, there were still positive for Shigella in one of the groups. On day 30 and 180 both had no positive results for Shigella. No adverse effects were evident during the feed trial. An entire colony (n=1000) was then treated with the medicated feed and no complications were reported. Serial fecal culture (n=3) from the colony six months post the epizootic, has yielded no positive results. Two years post epizootic no increased incidence of diarrhea or deaths have been identified within the colony. To the author’s knowledge, this is the first report of an epizoonosis of Shigella treated with medicated food in a free range colony of rhesus macaques.