Abstract # 147:

Scheduled for Friday, June 21, 2013 04:20 PM-04:35 PM: Session 20 (San Geronimo Ballroom C) Oral Presentation


FUNCTIONAL NEUROIMAGING OF SOCIOEMOTIONAL COGNITION IN RHESUS MONKEYS (MACACA MULATTA)

C. J. Machado
Department of Psychiatry and Behavioral Sciences, California National Primate Research Center, University of California, Davis, CA 95616, USA
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     Social and emotional behaviors appear to be mediated by complex, but mostly overlapping neural networks. However, most research in this field has involved invasive techniques (e.g., lesions and electrophysiological recordings) that typically target only one structure at a time and may result in structural or functional reorganization. We have adopted a whole-brain, noninvasive approach to study the neurobiology of socioemotional cognition in rhesus monkeys (Macaca mulatta). Using positron emission tomography (PET) and 2-deoxy-2[18F]fluoro-D-glucose (FDG), we measured cerebral glucose metabolism in adult males (n=5) under two conditions. One scan occurred after the animals watched videos showing conspecific social behavior during FDG uptake. A second (control) scan occurred after the animals watched videos showing groups of non-primate animals during FDG uptake. Visual scan paths and cardiac psychophysiology were also recorded and incorporated into a Partial Least Squares analysis of the PET data. We predicted that the amygdala, superior temporal sulcus, orbitofrontal cortex (OFC), anterior cingulate cortex (ACC) and frontal pole would be more active when the animals watched conspecific social behavior, relative to groups of heterospecifics. Glucose metabolism was indeed higher in the OFC, ACC and frontal pole for the conspecific social condition, relative to the heterospecific condition (all p<.05), especially when total fixation duration was included in the analysis. These results support the idea that these structures are critical for processing visual stimuli with socioemotional content.