Abstract # 70:

Scheduled for Saturday, September 13, 2014 07:00 PM-09:00 PM: Session 11 (Decatur B) Poster Presentation


T. R. Heitz1, A. Galvan1,2,3, T. Wichmann1,2,3 and L. A. Parr1,4,5
1Yerkes National Primate Research Center, Atlanta, GA, USA, 2Morris K. Udall Center of Excellence for Parkinson's Disease Research, Emory University, Atlanta, GA, USA , 3Department of Neurology, School of Medicine, Emory University, Atlanta, GA, USA, 4Department of Psychiatry and Behavioral Science, Emory University, Atlanta, GA, USA, 5Center for Translational Social Neuroscience, Emory University, Atlanta, GA, USA
     Monkeys treated with the neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydopyridine (MPTP) is the most common way to model the gross motor deficits associated with Parkinson’s disease (PD). In humans, partial facial paralysis is common but this is not commonly measured in monkeys. This study used MaqFACS, a biologically-based facial movement coding system for the Rhesus macaque, to measure the onset of facial paralysis associated with the progression towards PD in monkeys. Prior to treatment, we videotaped 11 monkeys (baseline) over a 4-week period and coded the frequency and duration of spontaneous facial movement using MaqFACS. Only two movements (AUs) showed instability across the baseline: AU17 (chin raiser) increased over the first three sessions and decreased in the final session, F(3,15) = 3.49, p < 0.05, and AU45 (blinks) increased steadily, F(3,15) = 4.34, p < 0.05. Changes from baseline in the frequency of each AU during MPTP treatment were then assessed in seven of these monkeys. This revealed significant decreases in the majority of AU’s, particularly those in the upper face, e.g., AU1+2 (brow raise), F(1, 6) = 13.11, p < 0.01, but significant increases in other movements, particularly those associated with the lower face, e.g., AU25 (lips part), F(1, 6) = 8.79, p < 0.03. These results indicate that MaqFACS could be a useful tool to track the progression of PD in a monkey model.