Abstract # 89:

Scheduled for Sunday, September 14, 2014 10:10 AM-10:25 AM: Session 14 (Mary Gay) Oral Presentation


RISK FACTORS FOR ALOPECIA AND HAIR CORTISOL IN RHESUS MACAQUES (MACACA MULATTA): PRELIMINARY FINDINGS

C. K. Lutz1, K. Coleman2, J. S. Meyer3, D. Arnold3, A. Hamel3, K. Rosenberg3 and M. A. Novak3
1Southwest National Primate Research Center, Texas Biomedical Research Institute, P.O. Box 760549, San Antonio, TX 78245-0549, USA, 2Oregon National Primate Research Center, 3Department of Psychology, University of Massachusetts
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     Alopecia is a multifaceted condition that occurs in nonhuman primates. The etiology of this condition is poorly understood given the numerous and diverse potential factors contributing to hair loss. The purpose of this study was to survey the extent of alopecia and hair cortisol in captive rhesus monkeys and to identify potential risk factors. Subjects were 103 rhesus monkeys (Macaca mulatta), 60 females and 43 males, aged 3.5-21 years (M=9.6±4.3) housed at two primate facilities. Photographs (left side, right side, back) and hair samples were collected from the animals while they were sedated for routine physicals. Photographs were analyzed using Image J software to calculate total hair loss, and hair samples (n=92) were assayed for cortisol. Hair cortisol was significantly correlated with alopecia (r(90)=0.535, p<0.001). Linear multiple regressions were conducted to assess the impact of intrinsic and extrinsic variables. There was a significant facility effect for both alopecia (b=12.36, p<0.005) and hair cortisol (b=20.09, p<0.01), and females had significantly higher levels of hair cortisol than did males (b=18.76, p<0.005). Average number of sedations per year was positively associated with both alopecia (b=1.75, p<0.05) and hair cortisol (b=4.28, p<0.05), but single housing and age were not related to either. These results suggest that alopecia can be affected by both intrinsic and environmental variables, but further research needs to be conducted. Supported by grants R24OD01180-15 and P51OD011133.