Abstract # 148:

Scheduled for Sunday, September 14, 2014 07:00 PM-09:00 PM: Session 22 (Decatur B) Poster Presentation


CHRONIC INTRANASAL OXYTOCIN AFFECTS SOCIAL PREFERENCE BEHAVIOR IN JUVENILE TITI MONKEYS (CALLICEBUS CUPREUS)

R. Arias del Razo1, T. A. Weinstein2, S. P. Mendoza2, M. Solomon3, S. Jacob4 and K. L. Bales1,2
1Department of Psychology, University of California Davis, Davis, California 95616, USA, 2California National Primate Research Center, University of California, Davis, California,, 3MIND Institute, University of California-Davis, Sacramento, CA, 4Department of Psychiatry University of Minnesota, Minneapolis, MN
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     Oxytocin (OT) is a neuropeptide hormone which plays a critical role in social bonding and recognition. We examined how developmental exposure to chronic intranasal OT affects juvenile titi monkeys’ social preference for their parents versus unfamiliar adult heterosexual pairs. Six males and five females were treated intranasally with either 0.8 IU/kg OT dissolved in 50 ul of saline (n=6) or saline (n=5) once per day from 12 to 18 months of age. Preference testing was conducted at 13 months. Subjects were tested for three hours in a three chamber setup; the subject occupied the center cage and stimulus pairs were in adjacent cages separated by grated windows, allowing social interactions between the subject and stimulus animals. We measured durations of time spent in proximity with the grated windows and manually touching the grated windows. A multivariate GLM revealed that juveniles that received OT spent less time in proximity with their parents as compared to animals treated with saline (F=6, p=.04). Juveniles treated with OT also spent a greater amount of time in proximity to the unfamiliar pair (F=38.26, p<.0001) and touching the unfamiliar pair’s grated window compared to juveniles receiving saline (F=10.53,p=.01). These results suggest that chronic OT treatment decreases interest in parents and increases attraction to strangers in juveniles as compared with saline-treated animals.