Abstract # 90:

Scheduled for Sunday, September 14, 2014 10:25 AM-10:40 AM: Session 14 (Mary Gay) Oral Presentation


FACILITY OF ORIGIN AFFECTS LATER ALOPECIA IN RHESUS MACAQUES

R. Kroeker, G. H. Lee, R. U. Bellanca, J. P. Thom and J. M. Worlein
Washington National Primate Research Center, HSB I-421, Box 357330, Seattle, WA 98195, USA
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     Alopecia affects a significant percentage of laboratory macaques. A recent multi-site survey reported 49% of rhesus macaques were affected overall, with large differences in rates noted among facilities (Lutz et al., 2013). In most cases the etiology remains unidentified, but differences in husbandry practices or alopecia recording procedures have been proposed to explain differences in alopecia rates among facilities. In this study, we examined the relationship between alopecia and an animal’s facility of origin from ratings taken quarterly at the Washington National Primate Center (WaNPRC) over a 2- year period. Subjects were 147 rhesus (Macaca mulatta) adults who were not pregnant or postpartum, who had resided at the WaNPRC for over 1 year, and whose origin was known to be from one of five primary suppliers for WaNPRC. Results of a sex x facility ANCOVA with animal age and length of residence at WaNPRC as covariates, revealed that an animal’s mean alopecia rating was significantly related to facility of origin (F(4, 136)=2.6, P=0.04). Alopecia was not significantly related to age, or length of residence at WaNRPC. Our findings suggest that previously reported facility differences in alopecia cannot be wholly explained by differences in husbandry practices or recording procedures, as origin differences persist even when animals are housed at our facility under similar conditions. Funded by NIH grants P51 OD010425 and R24OD0118015.