Abstract # 6024 Event # 102:

Scheduled for Sunday, September 14, 2014 11:30 AM-11:45 AM: Session 15 (Henry Oliver) Oral Presentation


V. Michopoulos, C. Moore, D. Toufexis, Z. Johnson and M. Wilson
Yerkes National Primate Research Ceneter, 954 Gatewood Dr., Atlanta, GA 30329, USA
     Social subordination in female macaques produces a number of stress-related phenotypes, including bouts of anhedonia and periods of inappetence. However, when maintained in a rich dietary environment in which a prudent, laboratory chow diet and a high fat, high sugar diet are available, these free-feeding monkeys double their caloric intake, eating significantly more than more dominant animals. Because chronic social stress produces a hypofunctional reward system, we assessed whether social subordination would result in decreased dopamine (DA) 2 receptor (DR2) using PET neuroimaging. Additionally, because signals from the stress hormone axis alter this DA pathway and sustain emotional feeding in subordinate females, we determined whether administration of the CRFR1 antagonist Antalarmin would reduce this augmented caloric intake and increase D2R levels. Our results indicate that social subordination was associated with widespread reductions in D2R, and administration of Antalarmin increased D2R in the left amygdala only in subordinate females. This change in D2R upon Antalarmin was coincident with a reduction in stress-induced caloric intake in subordinate females. The consumption of these calorically dense diets exacerbates stress hormone reactivity that likely functions to feed forward to further promote emotional feeding in adult females. Taken together, these data indicate that activation of CRFR1 may sustain stress-induced emotional feeding in subordinate females. Supported by NIH grants DK096983, MH081816, OD P51OD11132.