Abstract # 6029 Event # 103:

Scheduled for Sunday, September 14, 2014 11:45 AM-12:00 PM: Session 15 (Henry Oliver) Oral Presentation


C. A. Shively2,3, T. C. Register3, M. Z. Vitolins2, M. E. Wilson1 and S. E. Appt2
1Wake Forest School of Medicine, Dept Pathology, Comparative Medicine, Winston-Salem, NC 27157-1040, USA, 2Wake Forest School of Medicine, 3Wake Forest School of Medicine
     Emerging clinical data suggest an association between the consumption of a Western diet and increased self-reported stress. Emerging experimental data suggest that certain characteristics of a Western diet may acutely exacerbate physiological and behavioral stress responses. Our preliminary data suggest that the consumption of a Western diet exaggerates physiological responses to the chronic stress of social subordination. 24 hour heart rates (HRs) were recorded via telemetry from 42 adult female Macaca fascicularis at 3 time points: after prudent diet consumption for 6 months and after consuming a Western diet for 18 and 34 mos. Data were analyzed with a mixed model ANOVA. Subordinate HRs were higher on average while consuming the prudent diet but not statistically different (p=0.34). Social status differences emerged with time consuming the Western diet (18 months p=0.13, 34 months p=0.002). Subordinates also lost much of their HR circadian rhythm by 34 months (time X status interaction p=0.005). In contrast, dominant HRs changed very little with changing diet. These data suggest the Western diet may deleteriously affect the autonomic nervous system in chronically stressed subordinate but not dominants. Data will also be presented suggesting similar effects of Western versus Prudent diet on the hypothalamic-pituitary-adrenal axis. Together these observations support the hypothesis that a Western diet exacerbates physiological responses to chronic stress that may deleteriously affect health.