Abstract # 96:

Scheduled for Sunday, September 14, 2014 10:00 AM-10:15 AM: Session 15 (Henry Oliver) Oral Presentation


AN INTRODUCTION TO THE FEMALE MACAQUE MODEL OF SOCIAL SUBORDINATION STRESS

M. E. Wilson
Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
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     As the moderator of the symposium Interdisciplinary Approaches to the Study of Social Stress Effects on Health, I will present an overview of the female macaque model of social subordination. Previously published data from a number of laboratories using either rhesus or cynomolgus monkeys will be presented showing that social subordination impairs the regulation of the hypothalamic-pituitary-adrenal axis, characterized by a loss of glucocorticoid negative feedback, and produces a proinflammatory condition. As an introduction to the symposium, data will be presented showing that a consequence of this chronic stress is the emergence of a number of physiological and neurobehavioral phenotypes that mimic stress-induced disorders in girls and women. This information will provide the necessary background for each of the talks in the symposium illustrating the utility of this macaque model to better understanding mechanisms by which chronic social stress impacts health in people. Supported by DK 0969083, MH 081816, HD 46501, HD 077623, and OD P51OD11132.