Abstract # 6149 Event # 156:

Scheduled for Friday, June 19, 2015 04:00 PM-04:15 PM: (Cascade H) Oral Presentation


RISK FACTORS FOR ALOPECIA AND HAIR CORTISOL IN RHESUS MACAQUES (MACACA MULATTA): FURTHER EVALUATION

C. K. Lutz1, K. Coleman2, J. M. Worlein3, R. Kroeker3, M. Menard4, A. Hamel4, K. Rosenberg4, J. S. Meyer4 and M. A. Novak4
1Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245-0549, USA, 2Oregon National Primate Research Center, 3Washington National Primate Research Center, 4University of Massachusetts
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     Alopecia is a complex condition impacted by natural, clinical, behavioral, and environmental factors. The purpose of this study was to further assess alopecia and hair cortisol in captive rhesus monkeys and identify potential risk factors, focusing on experiences that occurred during the prior year. Subjects were 142 rhesus monkeys (92 females), housed at three National Primate Research Centers. Photographs (left side, right side, back) and hair samples were obtained from the animals while they were sedated for routine physicals. Photographs were analyzed using Image J software to calculate total hair loss, and hair samples were assayed for cortisol. Hair cortisol was correlated with alopecia overall (r(140)=0.277, p<0.005), and at Facility 1 (r(32)=0.559, p<0.005). Linear regressions were conducted to assess the impact of intrinsic and environmental variables obtained from the animal records. For alopecia, age (b=-0.061, p<0.001), proportion of year singly housed (b =-1.449, p<0.001), and their interaction (b=0.115, p<0.001) were the only significant contributors to the model. Hair cortisol differed by facility and was higher for females (b=13.263, p<0.005) and animals receiving more sedations (b=1.040, p<0.05). The number of location changes was also a significant contributor to the model for Facility 1 (b=8.977, p<0.01). These results demonstrate that alopecia and hair cortisol can be affected by both intrinsic and environmental variables, but these results also vary by facility. Supported by grants R24OD01180-15, P51OD011133, P51OD010425, P51OD011092.