Abstract # 6217 Poster # 103:

Scheduled for Thursday, June 18, 2015 06:00 PM-08:00 PM: (Cascade AJBCD) Poster Presentation


VARIATIONS IN THE MU-OPIOID RECEPTOR INFLUENCES MATERNAL BEHAVIOR AND INFANT OUTCOMES IN RHESUS MACAQUE

K. Willoughby, H. Page, S. Waters, M. Schwandt, C. Barr, S. Lindell, S. Suomi and J. Higley
Brigham Young University, 1220 SWKT, Provo, UT 84604, USA
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     Research shows that variation in an OPRM1 SNP (C77G) in rhesus monkey (Macaca mulatta) mothers and infants are associated with variation in mother-infant attachment and behavior. We propose a study that investigates the role of mu-opioid genotype variation in maternal and infant behaviors. Behavioral data measuring mother-infant behavior and other home-cage social interactions were collected from 42 mother-infant pairs. Subjects were genotyped for the OPRM1 genotype, and mixed design repeated measure ANOVAs were run using weekly measures of 18 mother-infant behaviors over the first 24 weeks of life, using the infants’ genotypes and sex as between-subject factors. Mother freezing (lack of activity and social proximity to conspecifics) was associated with infant genotype and infant sex (p= 0.04). Mothers of CG males expressed more freezing than mothers of CG females, whereas mothers of CC females exhibited more freezing than mothers of CC males. Maternal restraint showed a nearly significant sex by genotype interaction (p= 0.058), with mothers restraining CC males more than CC females, and mothers restraining CC infants more than CG infants. These results are consistent with other studies showing that the OPRM1 gene plays a role in mother-infant relationships, and that mothers of infants with the G allele behave differently than mothers of infants with the CC genotype, and add to the research by showing that it is likely mediated by infant sex.