Abstract # 248:

Scheduled for Saturday, June 20, 2015 01:15 PM-01:30 PM: (Cascade E) Oral Presentation


TAKE THE MONKEY AND RUN

K. A. Phillips1,2, M. K. Hambright3, K. Hewes1, B. M. Schilder4, C. N. Ross2,5 and S. D. Tardif2,6
1Trinity University, San Antonio, TX, USA, 2Southwest National Primate Research Center, 3College of Coastal Georgia, 4The George Washington University, 5Texas A&M University San Antonio, 6UTHSCSA
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     The common marmoset (Callithrix jacchus) is a small, New World primate that is used extensively in biomedical and behavioral research. This short-lived primate, with its small body size, ease of handling, and docile temperament, has emerged as a valuable model for aging and neurodegenerative research. A growing body of research has indicated exercise, aerobic exercise especially, imparts beneficial effects to normal aging. Understanding the mechanisms underlying these positive effects of exercise, and the degree to which exercise has neurotherapeutic effects, is an important research focus. Thus, developing techniques to engage marmosets in aerobic exercise would have great advantages. Here we describe the marmoset exercise ball (MEB) paradigm: a safe (for both experimenter and subjects), novel and effective means to engage marmosets in aerobic exercise. Young adult marmosets were trained to run on treadmills for 30 minutes a day, 3 days a week. Our training procedures allowed us to engage marmosets in this aerobic exercise within 4 weeks, and subjects maintained this frequency of exercise for 3 months. These techniques should be useful to researchers wishing to address physiological responses of exercise in a marmoset model.