Abstract # 6307 Event # 40:

Scheduled for Thursday, June 18, 2015 03:15 PM-03:30 PM: (Cascade E) Oral Presentation


RANK AND DOMINANCE UNCERTAINTY INFLUENCE PRO-INFLAMMATORY CYTOKINE AND VIRAL ANTIBODY LEVELS IN RHESUS MACAQUES (MACACA MULATTA)

J. J. Vandeleest, B. A. Beisner, D. L. Hannibal, J. P. Capitanio and B. McCowan
One Shields Avenue, University of California-Davis, Davis, CA 95616, USA
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     Both low social status and unpredictability have been associated with negative health outcomes in humans and non-human primates. Because unpredictability and low social status often co-occur, it is difficult to disentangle their independent contributions to health. We used social network techniques to quantify dominance rank and certainty in dominance relationships to examine their impact on pro-inflammatory cytokine levels and latent virus reactivation. We observed two large outdoor social groups of rhesus macaques (N=139) for 6 weeks at the California National Primate Research Center. Multi-level models were selected based on AIC (alpha=0.05). High rank was associated with higher IgG levels for herpes B and rhCMV, while for IL-6, mid-ranked animals’ levels were lower than those of either high- or low-ranked animals. Animals with more ambiguous dominance relationships had higher IgG for herpes B, CMV, and higher IL-6. We also found two significant interactions between rank and dominance certainty: 1) higher rank was associated with higher Lymphocrypto Virus IgG levels, but only for animals with more ambiguous dominance relationships, and 2) lower rank was associated with higher levels of TNF-a for animals with more certain dominance relationships whereas a small but opposite effect was true for animals with ambiguous dominance relationships. These results demonstrate that the impact of social status on health depends, in part, on the certainty of social relationships.