Abstract # 7978 Event # 185:

Scheduled for Monday, August 28, 2017 09:20 AM-09:40 AM: (Grand Ballroom) Oral Presentation


MARMOSETS AS A TRANSLATIONAL AGING MODEL

S. Tardif
Southwest National Primate Research Center, TBRI, PO Box 760549, San Antonio, TX 78245, USA
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     Interests in the marmoset as a nonhuman primate aging model begin to accelerate in the mid-2000s. Because marmosets have a fast maturation and short life span compared with more commonly used Old World monkey models, such as macaques, the aging research community began to explore the potential for this species as a translational aging model. In addition, the relative ease with which marmosets can be bred in a barrier environment enhances their value as a life-span model. Since that time, efforts to better define what aging actually looks like in marmosets has intensified and while we have a much better picture of marmoset aging that we did a decade ago, we still have much to explore before we have taken full advantage of the potential of this model. Important findings of the past decade include: (1) a refined definition of lifespan in this species and what affects age-specific survival; (2) assessments of age-related pathological changes; (3) development of functional phenotyping relevant to aging, such as activity, strength, body composition, cytokine profiling; (4) support of studies using the marmoset as a preclinical model to test intervention that may modulate the aging process.