Abstract # 188:

Scheduled for Monday, August 28, 2017 10:20 AM-10:40 AM: (Grand Ballroom) Oral Presentation


A. Lacreuse
University of Massachusetts, Department of Psychological and Brain Sciences, AMHERST, MA 01003, USA
     This presentation will discuss the hormonal modulation of cognition in marmosets, particularly in the context of aging and menopause. I will first present data from an ongoing longitudinal study showing sex differences in cognitive performance, stress reactivity and brain neurochemistry (as assessed by MRS) in middle-aged marmosets. The second part of the talk will focus on the effects of estrogen manipulations in the surgically menopausal female marmoset. I will show that estrogens not only affect cognition and stress reactivity, but also sleep and temperature patterns, underlining the importance of integrating multiple measures from the same animal for a better understanding of the impact of estrogen loss on aging patterns. Finally, I will present recent evidence that estrogen synthesis inhibition has detrimental effects on cognition, thermoregulation and neuronal physiology, suggesting an important contribution of neurostrogens in age-related cognitive decline. Overall, the results of these studies support the use of the marmoset as a translational model for neurocognitive aging. Supported by NIH R01 AG046266.