HORMONAL MODULATION OF NEUROCOGNITIVE AGING IN MARMOSETS (CALLITHRIX JACCHUS) |
A. Lacreuse
University of Massachusetts, Department of Psychological and Brain Sciences, AMHERST, MA 01003, USA |
 |
| This presentation will discuss the hormonal modulation of cognition in marmosets, particularly in the context of aging and menopause. I will first present data from an ongoing longitudinal study showing sex differences in cognitive performance, stress reactivity and brain neurochemistry (as assessed by MRS) in middle-aged marmosets. The second part of the talk will focus on the effects of estrogen manipulations in the surgically menopausal female marmoset. I will show that estrogens not only affect cognition and stress reactivity, but also sleep and temperature patterns, underlining the importance of integrating multiple measures from the same animal for a better understanding of the impact of estrogen loss on aging patterns. Finally, I will present recent evidence that estrogen synthesis inhibition has detrimental effects on cognition, thermoregulation and neuronal physiology, suggesting an important contribution of neurostrogens in age-related cognitive decline. Overall, the results of these studies support the use of the marmoset as a translational model for neurocognitive aging.
Supported by NIH R01 AG046266.
|
|
|