Abstract # 126:

Scheduled for Saturday, August 26, 2017 03:45 PM-04:00 AM: (Grand Ballroom) Oral Presentation


TREATMENT OF CHRONIC IDEOPATHIC DIARRHEA IN A PIGTAILED MACAQUE (MACACA NEMESTRINA) WITH FLUOXETINE

E. K. Hutchinson, S. P. Flemming, A. E. Goodroe and C. L. Kissel
Johns Hopkins University, 720 Rutland Ave, Ross 459, Baltimore, MD 21224, USA
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     An 11 y/o male pigtailed macaque with a normal rearing history and housed in a harem at the Johns Hopkins University breeding farm present with a history of chronic, idiopathic diarrhea and chronic, idiopathic diarrhea, both refractory to multimodal treatment. He was noted to have a milieu of behaviors that have elsewhere been described as being associated with serotonin dysfunction, and this guided our decision to attempt treatment with fluoxetine, a selective serotonin reuptake inhibitor, at a dose of 2 mg/kg by mouth once daily. In 178 days prior to initiating fluoxetine treatment, the animal’s fecal score averaged 3.12 (out of 4). In the 35 days following treatment, his average fecal score fell to 2.74. Furthermore, the 35-day average fecal score fell by 0.8 point during this time, and was lower than all but 12 of 144 such periods prior to beginning treatment. This result suggests that behavioral evaluation of animals with idiopathic diarrhea may yield information suggesting a psychological etiology, and thus guide appropriately targeted therapy.