Abstract # 81:

Scheduled for Thursday, August 18, 2005 07:00 PM-09:00 PM: (Cambridge/Oxford Room) Poster Presentation


EFFECTS OF ACUTE INTRAVENOUS ETHANOL ADMINISTRATION ON ORAL CONSUMPTION OF ETHANOL IN RHESUS MACAQUES

S. A. Chen, M. L. Schwandt, S. G. Lindell, C. S. Barr, T. K. Newman, S. J. Suomi and J. D. Higley
NIH/NIAAA, LCTS, NIHAC, Laboratory of Clinical and Translational Studies, NIH Animal Center, P.O. Box 529 Bldg 112 Rm 205, Poolesville, CA 20837, USA
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     The present study examined whether prior intravenous (IV) administration of ethanol (EtOH) would lead to an increased intake of oral EtOH in rhesus macaques. Also examined were differences in rearing conditions and sex. Subjects were reared with their mothers in social groups (MR) or without adults in peer-only groups (PR) and had no prior experience with ethanol. At a mean age of 3 years, the subjects were dosed with IV EtOH twice (experimenter-delivered), each dose separated by at least two weeks (males: 2.1 and females: 2.0 grams EtOH per kg body weight using a 16.8% EtOH solution that produced homogeneous blood alcohol concentrations between individuals and the sexes). The total volume of EtOH solution was infused over a 20-min period. Subjects then were trained to consume EtOH by exposing them to an aspartame-sweetened vehicle, until they freely consumed the vehicle. Then subjects were allowed to drink the EtOH aspartame-sweetened solution (8.4% EtOH; 1 hr/day; 5 days/week) across four consecutive weeks. A control group of non-IV EtOH pretreated subjects were similarly trained to drink. A mixed ANOVA revealed a significant interaction indicating increases in oral EtOH intake in IV EtOH-pretreated PR males and females, as compared with pretreated MR subjects and non-pretreated controls across four weeks of testing (F1, 3 = 7.21, P < 0.01). The results revealed that acute EtOH pre-exposure may yield increased EtOH consumption and that differences in rearing conditions may contribute significantly to this effect.