Abstract # 914 Poster # 183:

Scheduled for Friday, August 19, 2005 07:00 PM-09:00 PM: (Cambridge/Oxford Room) Poster Presentation


E. J. Rainwater1,2,3 and G. P. Sackett1,2,3
1University of Washington, IPRL CHDD, BOX 357920, University of Washington, Seattle, Washington 98195, USA, 2Center on Human Development and Disability, 3Washington National Primate Research Center
     This study aimed to identify promising phenotypic measures of social development for genetic analysis. Subjects were 498 nursery-reared, typically developing, 2-8 month old pigtail macaques, entering the study between birth and two postnatal weeks. All subjects had at least one paternal (57 sires, 372 offspring) or maternal (56 dams, 147 offspring) half siblings in the sample. Infants were socialized in 4-5 animal playgroups for 30-minutes, 5 days each week. The duration and frequency of total social, nonsocial, and self-directed activity, initiated interactions, and passive, play, explore, and negative behaviors were averaged from 5-minute daily focal observations at months 2 and 8. The potential for genetic analysis was assessed by the pattern of significant (P < 0.05) Intraclass Correlations derived from 1-Way ANOVAs between the half-sibling families. Self-directed and initiated behavior had paternal and maternal correlation in month 2, but not in month 8. Negative behavior showed the opposite pattern. Play had paternal and maternal association at both ages; with the maternal relationship double that of paternal. The opposite was true for nonsocial, passive and explore behaviors, with paternal stronger than maternal association. The results suggest that there may be meaningful genetic variation in infant social behavior, but genetic influence may change from early to later infancy for some behaviors, and some may be influenced differentially depending on parental source. Supported by NIH grants RR00166, HD02274.