Abstract # 169:

Scheduled for Friday, August 19, 2005 07:00 PM-09:00 PM: (Cambridge/Oxford Room) Poster Presentation


C. Kenney1, M. F. Novak1 and G. P. Sackett2
1Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, NIH Animal Center, Poolesville, MD 20837, USA, 2Infant Primate Research Laboratory and Washington National Primate Research Center, Seattle, Washington.
     Biobehavioral interactions between mother and fetus may increase understanding of the origins of fetal and infant reactivity to environmental change, however, such information is lacking due to difficulty in collecting longitudinal data on the fetus. Using tethering with maternal and fetal catheterization, starting at gestational day 120 (GD), this study assessed heart rate and blood pressure circadian rhythms in mother and fetus pigtailed macaque pairs (n = 4). Twenty-four hour data were collected from chronic catheters from GD 127 through the end of pregnancy (~ GD 165). Multiple regression and time series analyses were conducted to explore the relationship between maternal and fetal cardiovascular variables across the circadian cycle. Both fetal prediction of maternal status and maternal prediction of fetal status were explored after covarying intrauterine pressure to control for movement artifact. Fetal heart rate (FHR) predicted maternal heart rate (MHR) [ΔR2 = 0.175; F1, 29,647 = 8103.11; P < 0.001]. FHR also predicted maternal blood pressure (MBP) [ΔR2 = 0.067, F1, 29,647 = 2404.81; P < 0.001]. In contrast, fetal blood pressure (FBP) was unrelated to either MHR or MBP (ΔR2 = 0.000 and 0.005, respectively). Mother-fetus pairs exhibited some individual differences. Understanding these individual differences in cardiovascular profiles may assist in understanding origins of maternal-infant synchrony, infant emotion regulation, and even attachment behavior. More research is needed to explore the connection between pre- and postnatal biobehavioral development. NCRR-RR00166 CHDD/NICHD-HD02274.