Abstract # 56:

Scheduled for Thursday, August 18, 2005 07:00 PM-09:00 PM: (Cambridge/Oxford Room) Poster Presentation

The Effect of Relocation on Nighttime Activity and Salivary Cortisol in Singly-Housed Male Macaca mulatta With and Without a Record of Self-Injury

C. K. Lutz1, M. D. Davenport1,2, S. Tiefenbacher1, L. Sudalter1, K. M. Stonemetz1, V. Maguire1, J. S. Meyer2 and M. A. Novak1,2
1New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, P.O. Box 9102, Southborough, MA 01772, USA, 2Department of Psychology, University of Massachusetts, Amherst, MA
     Self-injurious behavior (SIB) is a serious condition occurring in human and nonhuman primate populations. Previous studies demonstrated an association between SIB and both stress and sleep disturbances. This study investigated these associations in rhesus monkeys before and after a planned move to a new building. Nineteen adult male Macaca mulatta, 13 with and 6 without a history of SIB, served as subjects for this study. They were videotaped from 9 pm to 3 am, before and after relocation. Eight saliva samples were collected per animal from 16 of the subjects, four during the week prior to, and four during the week following, the move. Overall activity and behaviors (abnormal, locomotion, scratch, self-groom, sleep, visual explore, other) were scored from the videotapes via 1-minute scan sampling. Locomotion increased and sleep decreased from pre- to post-move (P < 0.05), and there was a significant interaction; sleep decreased in SIB, but not non-SIB, subjects (P < 0.01). Salivary cortisol was higher after the move (P < 0.001), but there was no SIB effect. There was a positive correlation between change in cortisol and change in activity from pre- to post-move (P < 0.05). These results suggest that relocation can cause an increase in stress, as measured by salivary cortisol, in both SIB and non-SIB animals. However, SIB subjects are more likely to experience sleep disturbance after an environmental change. Supported by NCRR grants #RR11122 and #RR00168.