Abstract # 190:

Scheduled for Friday, August 19, 2005 07:00 PM-09:00 PM: (Cambridge/Oxford Room) Poster Presentation

An Association Between Gastric Regurgitation and Disease in Nonhuman Primates (Papio spp., Macaca nemestrina, Cercopithecus aethiops)

E. J. Glover, M. M. Leland and G. B. Hubbard
Southwest Foundation for Biomedical Research, Southwest Foundation for Biomedical Research, P.O. Box 760549, San Antonio, TX 78245-0549, USA
     Gastric regurgitation is frequently observed in captive nonhuman primates. Chronic regurgitation is known to result in a variety of disease conditions; however, considering disease as a cause of regurgitation in nonhuman primates has been largely overlooked. Reduction of regurgitation in nonhuman primates has focused primarily on the provision of environmental enrichment with only marginal success. A retrospective analysis of regurgitators in our colony was conducted. Eighty-six regurgitators were identified over a period of 10 years. Records for each individual were examined for disease conditions commonly associated with regurgitation. These were identified by endoscopy and histopathological examination of biopsy and necropsy tissue. Twenty-one animals were found to have at least one significant associated disease condition present. This number, however, is not likely to be a true representation because all regurgitators were not thoroughly examined medically or pathologically. Clinical symptoms most frequently observed in regurgitators were emaciation (n = 9), nasal discharge (n = 4), and diarrhea (n = 4). Pathological changes most frequently observed were lymphocytic changes including lymphosarcoma, lymphocytic esophagitis and enteritis (n = 9), nephritis (n = 6), and oral disease (n = 5). This trend suggests an association between certain disease conditions and regurgitation in nonhuman primates. Regurgitation may be indicative of underlying clinical disease and regurgitators may also be at risk for certain diseases due to the persistence of the behavior. Identifying causes and effects of regurgitation may assist in implementing more effective treatments.