Abstract # 241:

Scheduled for Thursday, August 9, 2001 02:45 PM-05:00 PM: Session 3 (University Hall 158) Roundtable

Roundtable: The Development, Maintenance, and Utilization of Colonies of Specific Pathogen Free (SPF) Macaques

R. Harrison1 and S. Schapiro2
1Tulane Regional Primate Research Center, Covington, LA 70433, 2The University of Texas M.D. Anderson Cancer Center
     As the complexity of biomedical investigation increases, the need for safe and well-defined animal models for research also increases. This is true even for nonhuman primate research, which is best conducted using macaque subjects that are not only free of pathogens that are potentially harmful to humans, but are also free of specific pathogens that might impact research questions. While currently employed management approaches aimed at optimizing the viral definition, health, genetic diversity, genetic definition, safety, behavior competence, and reproductive output of specific pathogen free (SPF) macaques have been relatively successful, the demand for SPF subjects is still far greater that the current supply. A strong consensus regarding the exact goals of an SPF macaque program is still lacking. Areas of discussion in the roundtable will include, but not be limited to: (1) Identification of the most critical pathogens for elimination from macaque colonies to achieve SPF status. (2) Testing procedures to identify, confirm, and maintain SPF status. (3) Housing options that minimize the potential for pathogen outbreaks while allowing for maximum production from the colony.(4) Strategies for addressing issues related to the availability of SPF monkeys for research. (5) Mechanisms for augmenting the production of increasingly well-defined SPF macaques. (6) Identification of means of support for the establishment and maintenance of SPF colonies. These issues and others will be addressed through presentations and discussion.