Abstract # 125:

Scheduled for Friday, August 18, 2006 02:45 PM-05:15 PM: Session 13 (Regency East #1) Symposium

The use of molecular genetics in behavior studies

J. Higley1 and J. Rogers2
1NIH Animal Center, P.O. Box 529, Bldg 112, Room 205, Poolesville, MD 20837-0529, USA, 2Southwest National Primate Research Center and Department of Genetics, Southwest Foundation for Biomedical Research
     With the emergence of molecular genetics, researchers studying nonhuman primate behavior have capitalized on monkeys' genetic similarity to humans and the capacity to hold the environment constant, showing how genetic influence is not homogeneous, influencing all individuals in the same manner. This symposium aims to present the state of nonhuman primate behavioral genetics research. Dr. Rogers will begin with an overview of the state of the field. In separate studies of the serotonin transporter (5HTT) genotype, Drs. McCormack and Sanchez will present data showing that when considering phenotypic outcomes one must consider gender, developmental history, and differing types of stress. Dr. Capitanio will present data showing that the 5HTT genotype can affect health outcomes in an infectious disease process. Dr. Suomi will present comparative data showing the absence or presence of the short 5HTT variant parallels different macaque species' temperaments. Dr Fairbanks will report data showing the DRD4 genotype’s influence on personality traits, and how maternal and infant genotypes interact to affect developmental pathways. Dr. Newman will report on novel, functional polymorphisms in the rhesus DRD4 and TPH2 genes, and their association with impulsivity and aggression. Dr. Cameron will present data showing that the influence of alcohol varies with genetic background. Dr. Barr will present CRH and NPY genotype data showing that the adaptation to stress is dependent on genotype, sex, and environmental interactions.