Abstract # 2314 Event # 17:

Scheduled for Thursday, June 21, 2007 01:15 PM-03:15 PM: Session 4 (North Main Hall C/D) Symposium

Self-Injury in Macaques: Behavior, Pharmacology and Neurobiology

C. L. Bethea
Divisions of Reproductive Sciences and Neuroscience, Oregon National Primate Res. Ctr., 505 NW 185th St., Beaverton, OR 97006, USA
     This symposium will review much of what we know about the etiology and neurobiology of self-injury in macaques. Dr. Cynthia Bethea will open the session with a single chart on characteristics of self-injury in patients with borderline personality disorder. Dr. Corrine Lutz will introduce the session with data on risk factors for self-injurious behavior (SIB) such as sex, age, housing, rearing, triggers, and association of SIB with aggression or stress, and extinction deficits. Dr. Kathy Bentson will focus on animals exhibiting self-biting without skin trauma and floating limb activity. Data will be presented on the levels of cortisol, adrenocorticotropin, b-endorphin fragments, dopamine receptors in basal ganglia tissue and outcomes of acepromazine or diazepam treatments. Dr. Melinda Novak will present data on the physiological and genetic parameters of SIB along with drug intervention studies. Dr. J. Dee Higley will present data showing early experiences that interact to increase the risk for SIB, the involvement of the serotonin system, and positive outcomes from administration of serotonin agents. Dr. Jessica Henderson will present data on western blot analysis of serotonin-related proteins in the midbrain raphe area of male and female macaques that were euthanized for SIB versus chronic diarrhea or clinical training. Proteins examined included tryptophan hydroxylase, 5HT1A autoreceptor, 5HT2A receptor, 5HT2C receptor, and the serotonin reuptake transporter.