Abstract # 7952 Event # 184:

Scheduled for Monday, August 28, 2017 09:20 AM-11:30 AM: (Grand Ballroom) Symposium


MARMOSETS AS A TRANSLATIONAL MODEL FOR AGING STUDIES

C. N. Ross1,2,3, N. Nadon4 and F. Macchiarini4
1Texas A&M University San Antonio, De, One University Way, San Antonio, TX 78224, USA, 2University of Texas Health San Antonio - Barshop Institute for Longevity and Aging, 3Southwest National Primate Research Center, 4National Institute of Aging, NIH
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     While advances in medical care have resulted in increased human lifespan we have made relatively few advances in increasing human healthspan. Additionally, it is now believed that many of the pillars of aging are associated with diseases such as dementia, frailty, and cancer. Treatment of aging systemically will not only increase life span but also reduce age related disease incidence. The use of an animal model to evaluate cellular, mechanistic and phenotypic processes of aging offers the advantage of being able to control environmental exposure to variables including nutrition and infection, as well as maintain lifelong confirmed medical history of the individual. The marmoset offers a unique nonhuman primate model for aging studies. Marmosets have a short lifespan when compared to other primates, they are cheap to house, have high fecundity, and they are small making them easy and safe to handle for experimentation. Marmosets have been found to display many aging phenotypes that mimic human aging including increased risks of cardiovascular changes, inflammatory disease, and decreases in cognition. This symposium will highlight the expanding base of knowledge we have regarding marmoset aging and their use as a model of aging disease processes. The emergence of this animal model is particularly important for this meeting of ASP in DC as it presents the opportunity to update not only the ASP community but also the NIH participants that might not be familiar with marmosets.