Abstract # 13183 Event # 21:

Scheduled for Thursday, August 9, 2018 09:00 AM-10:00 AM: (Regency West 1/3) Featured Speaker


FROM BOWEL TO BRAIN: GUT MICROBIOTA DIVERSITY AND CHRONIC HPA AXIS ACTIVITY ACROSS DEVELOPMENT IN RHESUS MONKEYS

A. M. Dettmer3, J. Allen4, V. A. Varaljay 4, R. M. Jaggers4, A. M. Murphy5, S. J. Suomi2, J. S. Meyer1 and M. T. Bailey4
1AAAS Science & Technology Policy Fellow, Sponsored by the American Psychological Association, Institute of Education Sciences, Washington, DC 20024, USA, 2Laboratory of Comparative Ethology, NICHD/NIH, Poolesville, MD, 20837, USA, 3AAAS Science & Technology Policy Fellow, 4Center for Microbial Pathogenesis, The Research Institute at Nationwide Children’s Hospital, Columbus, OH, 43205, USA, 5Department of Psychology, University of California, Davis and California National Primate Research Center, University of California, Davis, Davis, CA 95616
line
     Within days of birth, mammals undergo commensal intestinal bacterial colonization that remains throughout life. The commensal microbiota is critical for immune function, nutrient processing, and central nervous system functioning, including that of the hypothalamic-pituitary-adrenal (HPA) axis. Though it is established that nursery-reared (NR) monkeys exhibit higher long-term cortisol concentrations than mother-peer-reared (MPR) monkeys, nonhuman primates are notably absent from the literature demonstrating that gut microbiota program the HPA axis early in life. With support from the 2015 ASP Legacy Award, we tested the hypothesis that gut microbial diversity would relate to chronic HPA axis activity, as measured in hair cortisol concentrations (HCCs), across early development in rhesus monkeys (Macaca mulatta, N=19-35). We obtained DNA samples from rectal swabs and hair samples on the day of birth and at six intervals throughout the first year of life. NR infants had lower relative Lactobacillus than MPR infants at 30d (t(1)=3.39,p=0.002) and 6mos (t(1)=1.98,p=0.03), and higher Bifidobacterium at 30d (t(1)=-2.50,p=0.01). Relative levels of Lactobacillus (r=0.48,p=0.06) and Streptococcus (r=0.53,p=0.03) at 6mos were positively correlated with changes in HCCs from 6-9mos for NR infants. These first findings in neonatal NHPs indicate that gut microbial diversity is associated with altered chronic HPA axis activity.