Abstract # 2185 Event # 37:

Scheduled for Thursday, June 21, 2007 03:30 PM-04:30 PM: (North Main Hall) Featured Speaker

Mobile Elements and Primate Genomic Variation

M. A. Batzer
Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, Baton Rouge, LA 70803, USA
     Mobile elements belong to discrete subfamilies that can be differentiated from one another by diagnostic nucleotide substitutions. An analysis of several recently integrated mobile element subfamilies was undertaken to assess mobile element associated primate genomic diversity. Our screening of the mobile element insertion loci resulted in the recovery of a number of "young" mobile elements with different distributions throughout the primate lineage. Many of the mobile elements recovered from the human genome were restricted to the human lineage, with some elements that were polymorphic for insertion presence/absence in diverse human populations. These loci have proven useful for elucidating human population relationships. Additional lineage specific mobile element insertions have been recovered from the genomes of a variety of non-human primates. The distribution of these elements throughout various primate genomes makes them useful tools for resolving non-human primate systematic relationships. The expansion of mobile elements within the primate lineage has had a significant impact on the structure of primate genomes. We have identified several genomic deletions associated with the retrotransposition and insertion of mobile elements in primate genomes. This type of retrotransposition mediated genomic deletion is a novel source of genetic variation within primates. We have also identified multiple examples of mobile element mediated genomic sequence transduction, including the generation of a new gene family in the primate order.