Abstract # 81:

Scheduled for Friday, June 22, 2007 09:30 AM-12:10 PM: Session 8 (North Main Hall C/D) Symposium

Contributions of a Macaque Model of Women's Health

C. A. Shively and T. B. Clarkson
Wake Forest Univ. School of Medicine, Comparative Medicine, Medical Center Blvd., Winston-Salem, NC 27157-1040, USA
     Animal modeling of human health historically has ignored sex differences, or developed models in males largely for the sake of convenience. This symposium addresses the use of socially housed laboratory macaques (Macaca sp.) to model critical health concerns of women. The following topics are addressed: The effects of dietary phytoestrogens, found in abundance in monkey chow, on cell proliferation, breast and endometrial cancer risk; similarities between human and macaque genital papillomaviruses which cause cervical cancer in women; development of an ovary-intact model of the perimenopausal transition and menopause which includes gradual ovarian failure and a hormone profile similar to women; the impact of mammalian estrogens and dietary phytoestrogens, including those found in monkey chow, on obesity and insulin resistance; adult reproductive life stage and extent of atherosclerosis as major determinants of the cardiovascular benefits of estrogen; estrogen and dietary phytoestrogen-sensitive inflammatory processes and atherosclerosis; modeling the co-morbidity of social stress-related depression and coronary heart disease risk; and the age dependent effects of estrogen on attention and memory in adult female macaques. The research presented is multi-disciplinary and includes multiple levels of analysis. A central theme of this symposium is the critical need for more female nonhuman primates in basic and pre-clinical research to provide a rationale scientific basis for clinical investigations in women’s health.