Abstract # 95:

Scheduled for Sunday, September 14, 2014 10:00 AM-12:00 PM: Session 15 (Henry Oliver) Symposium


C. A. Shively1, M. E. Wilson2, M. M. Sanchez2, Z. P. Johnson2, G. N. Neigh2, M. G. Silverstein1, S. L. Willard3 and V. J. Michopoulos2
1Wake Forest School of Medicine, Dept Pathology, Comparative Medicine, Winston-Salem, NC 27157-1040, USA, 2Emory University, 3University of Pennsylvania
     Social subordination stress in female macaques has profound effects on health. The behavioral and biological effects of this stressor will be examined from multiple perspectives in this symposium. Social subordination affects the development of neural circuitry involved in emotional behavior and the regulation of stress responses. Social subordination results in different patterns of inflammatory gene expression, and alters immune responses that result in higher viral load in chronic infection. Selective serotonin reuptake inhibitors (SSRIs), prescribed for a wide array of disorders, have differential effects on dominants and subordinates, suggesting that preexisting physiology associated with chronic stress modulates neural and systemic responses to these ubiquitously prescribed medications. In an environment of over-nutrition social subordination results in greater caloric intake, likely contributing to obesity in laboratory-housed nonhuman primates (NHPs) and human beings. Finally, emerging data suggest that consuming a typical American diet enriched in cholesterol, with fats and proteins derived mainly from animal sources, results in exaggerated physiological stress responses which are far more pronounced in subordinates than dominants. These observations emphasize the important role of social stress in the health of human beings and laboratory-housed NHPs.